GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs1577917 | 1 | rs1415753 | chr6:86753074 | SNHG5 | chr6:86386726-86388451:- | -0.59 | -7.1 | 2.21E-10 | Response to antipsychotic treatment |
| THYM | cis | rs10461617 | 1 | rs1423620 | chr5:56100996 | C5orf35 | chr5:56205103-56213010:+ | 0.74 | 9.25 | 6.53E-15 | Type 2 diabetes |
| THYM | cis | rs10461617 | 1 | rs1423621 | chr5:56101035 | C5orf35 | chr5:56205103-56213010:+ | 0.74 | 9.25 | 6.53E-15 | Type 2 diabetes |
| THYM | cis | rs7565981 | 1 | rs1435509 | chr2:101419792 | PDCL3 | chr2:101179418-101193201:+ | 0.55 | 4.47 | 2.15E-5 | Creutzfeldt-Jakob disease (variant) |
| THYM | cis | rs1451375 | 1 | rs1451374 | chr7:50622653 | FIGNL1 | chr7:50511834-50518088:- | -0.3 | -4.64 | 1.09E-5 | Malaria |
| THYM | cis | rs1451375 | 1 | rs1451375 | chr7:50622712 | FIGNL1 | chr7:50511834-50518088:- | 0.3 | 4.64 | 1.09E-5 | Malaria |
| THYM | cis | rs9475752 | 1 | rs1451707 | chr6:56801877 | BEND6 | chr6:56819773-56892138:+ | -0.49 | -4.54 | 1.66E-5 | Menarche (age at onset) |
| THYM | cis | rs9475752 | 1 | rs1451708 | chr6:56802201 | BEND6 | chr6:56819773-56892138:+ | -0.49 | -4.54 | 1.66E-5 | Menarche (age at onset) |
| THYM | cis | rs9876781 | 1 | rs1459242 | chr3:48413537 | TREX1 | chr3:48501186-48509043:+ | 0.28 | 4.42 | 2.61E-5 | Longevity |
| THYM | cis | rs17761864 | 1 | rs1466389 | chr17:2096384 | SRR | chr17:2207248-2228553:+ | -0.48 | -5.18 | 1.22E-6 | Esophageal cancer (squamous cell) |
| THYM | cis | rs7552404 | 1 | rs1498312 | chr1:76177849 | ACADM | chr1:76190043-76229353:+ | 0.3 | 4.24 | 5.21E-5 | Blood metabolite levels;Acylcarnitine levels |
| THYM | cis | rs7552404 | 1 | rs1498315 | chr1:76159225 | ACADM | chr1:76190043-76229353:+ | 0.3 | 4.24 | 5.21E-5 | Blood metabolite levels;Acylcarnitine levels |
| THYM | cis | rs10935120 | 1 | rs1498718 | chr3:134205920 | ANAPC13 | chr3:134196547-134204865:- | 0.57 | 7.72 | 1.16E-11 | Height |
| THYM | cis | rs10935120 | 1 | rs1498718 | chr3:134205920 | CEP63 | chr3:134204575-134293852:+ | 0.41 | 5.95 | 4.4E-8 | Height |
| THYM | cis | rs2243480 | 1 | rs1499613 | chr7:65730860 | CCT6P1 | chr7:65216092-65228661:+ | -0.64 | -5.29 | 7.77E-7 | Diabetic kidney disease |